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Translational Scientists

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Catherine Goddard, PhD
Discovery Translational Medicine
Wyeth Research

Phone: +44 (0) 1382 386361
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Specialist therapeutic areas: Cardiovascular, Metabolic Diseases, Inflammation and Drug Safety.  Catharine joined Wyeth and TMRC in Oct 2006 from the University of Cambridge, UK. Catharine’s training and research have developed core competencies in molecular biology, genetics and physiology. Catharine’s research prior to TMRC focussed on the use of animal models to further understanding and treatment of human disease. Catharine’s in vivo gene therapy studies on cystic fibrosis knock-out mice were critical in allowing a phase I clinical trial to proceed and Catharine also developed in vivo and ex vivo models to test gene therapy vectors. Her studies on models of cardiac arrhythmia have provided novel data on the mechanisms of arrhythmia and the action of anti-arrhythmic drugs. As a translational scientist for Wyeth and TMRC Catharine has spearheaded the initiation of research proposals in key areas of translational medicine need such as: biomarkers of ‘vulnerable plaque’; cardiovascular and liver safety biomarkers; target validation for anti-arrhythmic drugs.
Selected Publications

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Grant Sellar, DPhil
Discovery Translational Medicine
Wyeth Research

Phone: +44 (0) 1382 386360
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Grant Sellar is the Oncology Translational Scientist within TMRC, having joined Wyeth in Feb 2007. Grant attained his B.Sc. and D.Phil at Oxford in 1986 and 1989 respectively. Following successful Post Doctoral positions at Harvard Medical School and Children’s Hospital, Boston; Department of Genetics, Trinity College Dublin; and MRC Human Genetics Unit, Edinburgh, Grant continued his research with an Oncology focus at the Cancer Research UK Centre in Edinburgh from 1997 until his current post. His work there, initiallly as a postdoctoral fellow and laterally as an independent Cancer Research UK scientist leading the ovarian cancer genetics group. Centred on the identification of OPCML as an ovarian cancer tumour suppressor gene primarily inactivated by CpG island methylation, extensive molecular profiling of an in vitro ovarian cancer cell line model expressing OPCML and detailed investigation of the tumour suppressor gene family in epithelial ovarian cancer and in normal ovarian biology. Grant was the recipient of prestigious Fellowships during his postdoctoral career having being awarded a Beit Memorial Fellowship for Medical Research and a Royal Society of Edinburgh/Caledonian Research Foundation Fellowship for his research in Trinity College, Dublin and MRC HGU, Edinburgh, respectively.
Selected Publications
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